mobiLAB-4D Mobile measuring system for 4D quality control of implant surfaces in the synchrotron
Short project description
The demands on implant materials are becoming ever greater due to the increasing number of implantations and the higher expected age of patients. The effects of the surface structure of implants on clinical complications, such as infection or lack of osseointegration, have not been conclusively investigated. In particular, the role of nano- or microparticles that escape from the implants into the surrounding tissue is the subject of current research and development as well as regulatory innovations in connection with risk assessment.
Local exposure to metallic abrasion and corrosion products is a well-known problem in dental prosthetics. This can lead to increased local inflammation or hypersensitivity reactions. This results in inflammatory reactions in the surrounding tissue (peri-implantitis) and loss of quality of the peri-implant bone (osteolysis), whereby osteolysis can lead to early failure of the implant. Against this background, four clinically relevant questions are addressed in the project:
- Release of nanoparticles
- Toxicological risk assessment
- Insufficient osseointegration
The overarching goal of this project is a significant reduction in possible complications after inserting an implant. This is to be achieved through the development of novel implant surfaces and their preclinical testing with regard to biocompatibility. For this purpose, a transport unit for organ-on-a-chip systems and a measuring chamber for time-resolved measurements in the synchrotron are being developed.
The project focuses on dental implants, but the results can also be transferred to other titanium-based implants (e.g. hip and knee implants). The development of novel implant surfaces in combination with meaningful, preclinical in vitro testing can serve as a model for future regulatory processes.
- Xploraytion GmbH
- Charité Universitätsmedizin
- Fraunhofer IPK
- Laser-Mikrotechnologie Dr. Kieburg GmbH
- Universitätsmedizin Greifswald
- TissUse GmbH
- A.K.TEK Medizintechnik GmbH
This project was co-financed by the European Regional Development Fund (ERDF).